Manganese Exposure from Drinking Water and Children’s Classroom Behavior in Bangladesh

نویسندگان

  • Khalid Khan
  • Pam Factor-Litvak
  • Gail A. Wasserman
  • Xinhua Liu
  • Ershad Ahmed
  • Faruque Parvez
  • Vesna Slavkovich
  • Diane Levy
  • Jacob Mey
  • Alexander van Geen
  • Joseph H. Graziano
چکیده

BACKGROUND Evidence of neurological, cognitive, and neuropsychological effects of manganese (Mn) exposure from drinking water (WMn) in children has generated widespread public health concern. At elevated exposures, Mn has been associated with increased levels of externalizing behaviors, including irritability, aggression, and impulsivity. Little is known about potential effects at lower exposures, especially in children. Moreover, little is known regarding potential interactions between exposure to Mn and other metals, especially arsenic (As). OBJECTIVES We conducted a cross-sectional study of 201 children to investigate associations of Mn and As in tube well water with classroom behavior among elementary school children, 8-11 years of age, in Araihazar, Bangladesh. METHODS Data on exposures and behavioral outcomes were collected from the participants at the baseline of an ongoing longitudinal study of child intelligence. Study children were rated by their school teachers on externalizing and internalizing items of classroom behavior using the standardized Child Behavior Checklist-Teacher's Report Form (CBCL-TRF). RESULTS Log-transformed WMn was positively and significantly associated with TRF internalizing [estimated β = 0.82; 95% confidence interval (CI), 0.08-1.56; p = 0.03], TRF externalizing (estimated β = 2.59; 95% CI, 0.81-4.37; p =0.004), and TRF total scores (estimated β = 3.35; 95% CI, 0.86-5.83; p = 0.008) in models that adjusted for log-transformed water arsenic (WAs) and sociodemographic covariates. We also observed a positive monotonic dose-response relationship between WMn and TRF externalizing and TRF total scores among the participants of the study. We did not find any significant associations between WAs and various scales of TRF scores. CONCLUSION These observations reinforce the growing concern regarding the neurotoxicologic effects of WMn in children.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Manganese in Drinking Water and Cognitive Abilities and Behavior at 10 Years of Age: A Prospective Cohort Study

BACKGROUND Cross-sectional studies have indicated impaired neurodevelopment with elevated drinking water manganese concentrations (W-Mn), but potential susceptible exposure windows are unknown. OBJECTIVES We prospectively evaluated the effects of W-Mn, from fetal life to school age, on children's cognitive abilities and behavior. METHODS We assessed cognitive abilities and behavior in 1,265...

متن کامل

Water Arsenic Exposure and Children’s Intellectual Function in Araihazar, Bangladesh

Exposure to arsenic has long been known to have neurologic consequences in adults, but to date there are no well-controlled studies in children. We report results of a cross-sectional investigation of intellectual function in 201 children 10 years of age whose parents participate in our ongoing prospective cohort study examining health effects of As exposure in 12,000 residents of Araihazar, Ba...

متن کامل

Water Manganese Exposure and Children’s Intellectual Function in Araihazar, Bangladesh

Exposure to manganese via inhalation has long been known to elicit neurotoxicity in adults, but little is known about possible consequences of exposure via drinking water. In this study, we report results of a cross-sectional investigation of intellectual function in 142 10-year-old children in Araihazar, Bangladesh, who had been consuming tube-well water with an average concentration of 793 mi...

متن کامل

Association between Manganese Exposure through Drinking Water and Infant Mortality in Bangladesh

BACKGROUND Manganese is a common natural contaminant of groundwater in Bangladesh. In this cross-sectional study we assessed the association between water manganese and all-cause infant mortality in the offspring of female participants in the Health Effects of Arsenic Longitudinal Study Cohort. METHODS In 2001, drinking water samples were collected, a history of well use was obtained, and a h...

متن کامل

Section 1: Highlights for 2004 Highlight #1: an Association between Arsenic in Drinking Water and Cognitive Function in Children in Bangladesh

In Bangladesh, approximately 30-40 million people have been chronically exposed to high concentrations of naturally occurring arsenic (As) in drinking water, supplied by approximately 10 million tube wells. Aside from carcinogenic and vascular effects, the literature contains reports of neurologic consequences of acute and chronic exposure in adults, although the dosimetry is poorly described. ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره 119  شماره 

صفحات  -

تاریخ انتشار 2011